This session will review common misconceptions, important details, and current topics related to Human Subjects Protection (HSP) and Good Clinical Practice (GCP) in clinical trial administration and operations. Using an engaging format, we will discern truths, clarify best practices, and delve deeper into answers with referenced insights. When myths are identified, we will discuss how they start and ways to prevent them. Additionally, we will evaluate compliance questions, common interpretations, and site processes in comparison to requirements, rules, and regulations to recommend solutions for issues spanning various types and complexities.