Data and Safety Monitoring Boards (DSMBs) play a vital role in the continuing review of clinical trials. A panel of independent experts reviews study data related to participant safety and has the authority and responsibility to determine if a study may continue as is, require revision, or should terminate if the data reveals significant risk/harm to participants or indicates the statistical endpoints have been met. This session explores how DSMBs work and how they interact with research teams, HRPPs/IRBs, and sponsors.